About Enhancer
| Enhancer ID: | E_01059 |
| Species: | Homo sapiens |
| Position : | chr19:15311000-15312500   |
| Year: | 2020 |
| Title: | Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 33219226 |
| MONDO: | MONDO:0005032 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A549 |
| CVCL ID: | CVCL_0023 |
| Cell Type: | lung adenocarcinoma cell |
| Cell Ontology ID: | CL:0001069 |
| Experiment Type: | Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | NOTCH3 |
About TF
| TF name : | NRF2; CEBPB; FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer