About Enhancer
| Enhancer ID: | E_01070 |
| Species: | Homo sapiens |
| Position : | chr7:116735000-116735500   |
| Year: | 2014 |
| Title: | Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 24443471 |
| MONDO: | MONDO:0008315 |
| Tissue: | Prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | C4-2B |
| CVCL ID: | CVCL_4784 |
| Cell Type: | prostate carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | 3C, ChIP-RT-qPCR, CRISPR Knockout/CRISPRi, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | MET |
About TF
| TF name : | MITF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MITF | IL6-mediated signaling events | pid | 48 |
| MITF | KitReceptor | netpath | 104 |
| MITF | RANKL | netpath | 84 |
| MITF | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| MITF | Regulation of retinoblastoma protein | pid | 67 |
| MITF | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| MITF | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| MITF | SUMOylation of transcription factors | reactome | 14 |
| MITF | Melanogenesis | kegg | 100 |
| MITF | Pathways in cancer | kegg | 321 |
| MITF | Melanoma | kegg | 69 |
| MITF | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| MITF | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| MITF | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer