About Enhancer
| Enhancer ID: | E_01084 |
| Species: | Homo sapiens |
| Position : | chr4:15581130-15619993   |
| Year: | 2020 |
| Title: | H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 32242051 |
| MONDO: | MONDO:0004945 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 11 |
| CVCL ID: | CVCL_1312 |
| Cell Type: | B lymphoblast |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, 3C-seq (Capture-C), RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | TAPT1 |
About TF
| TF name : | MLL-AF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00721 | chr4:15581130-15619993 | Bone Marrow | B lymphoblast | acute lymphoblastic leukemia |
| E_00722 | chr4:15581130-15619993 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00723 | chr4:15581130-15619993 | Bone Marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01081 | chr4:15581130-15619993 | Embryonic Kidney | embryonic kidney cell | -- |
| E_01082 | chr4:15581130-15619993 | Bone Marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01083 | chr4:15581130-15619993 | Bone Marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer