About Enhancer
| Enhancer ID: | E_01085 |
| Species: | Homo sapiens |
| Position : | chr2:16370000-16380000   |
| Year: | 2020 |
| Title: | Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 33199677 |
| MONDO: | MONDO:0004945 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary MLL-AF4 ALL patient blasts |
| CVCL ID: | |
| Cell Type: | B lymphoblast |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq, 3C-seq |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR |
About Target Gene
| Target gene : | MYCN |
About TF
| TF name : | PHOX2B; HAND2; GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01086 | chr2:16370000-16380000 | Adrenal gland | neuroblastoma cell | neuroblastoma |
Expression of Target Genes for the Enhancer