About Enhancer
| Enhancer ID: | E_01095 |
| Species: | Mus musculus |
| Position : | chr9:119377827-119389749   |
| Year: | 2019 |
| Title: | An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31666509 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | mouse heart/cardiomyocytes |
| Cell Type: | cardiac muscle cell |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Canonical RE6-9 cluster; deletion reduces Scn5a and alters topology; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | RNA-seq; H3K27ac ChIP-seq; 4C-seq |
| Low Throughput Method: | Genome editing/deletion mouse; transgenic reporter; luciferase assay; RT-qPCR; ECG/conduction phenotyping; CRISPR-Cas9 endogenous deletion/editing; In vivo phenotyping |
About Target Gene
| Target gene : | Scn5a |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer