About Enhancer
| Enhancer ID: | E_01114 |
| Species: | Homo sapiens |
| Position : | chr6:35636622-35642872   |
| Year: | 2010 |
| Title: | Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 20093418 |
| MONDO: | MONDO:0005032 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A549 cell line |
| CVCL ID: | CVCL_0023 |
| Cell Type: | lung adenocarcinoma cell |
| Cell Ontology ID: | CL:0001069 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay |
About Target Gene
| Target gene : | FKBP5 |
About TF
| TF name : | NR3C1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR3C1 | AndrogenReceptor | netpath | 167 |
| NR3C1 | AP-1 transcription factor network | pid | 71 |
| NR3C1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| NR3C1 | Cellular roles of Anthrax toxin | pid | 25 |
| NR3C1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| NR3C1 | Glucocorticoid receptor regulatory network | pid | 85 |
| NR3C1 | IL2 | netpath | 81 |
| NR3C1 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR3C1 | PTK6 Expression | reactome | 5 |
| NR3C1 | Regulation of Androgen receptor activity | pid | 54 |
| NR3C1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| NR3C1 | Signaling events mediated by HDAC Class II | pid | 58 |
| NR3C1 | Neuroactive ligand-receptor interaction | kegg | 272 |
| NR3C1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| NR3C1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| NR3C1 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| NR3C1 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
| NR3C1 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer