About Enhancer
| Enhancer ID: | E_01134 |
| Species: | Homo sapiens |
| Position : | chr8:11446898-11447336   |
| Year: | 2022 |
| Title: | A risk variant for Barrett's esophagus and esophageal adenocarcinoma at chr8p231 affects enhancer activity and implicates multiple gene targets |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal adenocarcinoma |
| PMID: | 35766871 |
| MONDO: | MONDO:0004973 |
| Tissue: | Esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | OE19 |
| CVCL ID: | CVCL_1302 |
| Cell Type: | esophageal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-qPCR |
About Target Gene
| Target gene : | CTSB |
About TF
| TF name : | KLF4; KLF1; KLF3; KLF9; KLF14; KLF16; ZEB1; RUNX1; RUNX2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01133 | chr8:11446898-11447336 | Prostate | prostate epithelial cell | -- |
Expression of Target Genes for the Enhancer