About Enhancer
| Enhancer ID: | E_01142 |
| Species: | Mus musculus |
| Position : | chr9:119378700-119379271   |
| Year: | 2019 |
| Title: | An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31666509 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Mouse cardiomyocyte cell |
| Cell Type: | cardiac muscle cell |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-RT-qPCR, Western blot; CRISPR-Cas9 endogenous deletion/editing; In vivo phenotyping |
About Target Gene
| Target gene : | Scn5a |
About TF
| TF name : | Tbx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx5 | Physiological factors | reactome | 12 |
| Tbx5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Tbx5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer