About Enhancer
| Enhancer ID: | E_01151 |
| Species: | Homo sapiens |
| Position : | chr21:36179867-36180107   |
| Year: | 2020 |
| Title: | Disruption of super-enhancer-driven tumor suppressor gene RCAN14 expression promotes the malignancy of breast carcinoma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 32772967 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | BT549 |
| CVCL ID: | CVCL_1082 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-qPCR, RT-qPCR, Site-directed Mutagenesis, Western blot |
About Target Gene
| Target gene : | RCAN1.4 |
About TF
| TF name : | RUNX3; BRD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00764 | chr21:36179867-36180107 | Breast | mammary epithelial cell | -- |
| E_01149 | chr21:36179867-36180107 | Breast | mammary epithelial cell | -- |
| E_01150 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01152 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01153 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
| E_01154 | chr21:36179867-36180107 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer