About Enhancer
| Enhancer ID: | E_01166 |
| Species: | Mus musculus |
| Position : | chr8:121503787-121504483   |
| Year: | 2019 |
| Title: | Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31406378 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | common dendritic cell progenitors and pre-cDC1 |
| Cell Type: | dendritic cell progenitor |
| Experiment Type: | Chromatin accessibility assay; Functional perturbation assay; In vivo enhancer deletion assay |
| High Throughput Method: | ATAC-seq; H3K27ac ChIP-seq; H3K4me1 ChIP-seq; chromatin profiling |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; E-box deletion analysis; RT-qPCR; flow cytometry; Flt3L bone-marrow differentiation assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm39)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01346 | chr8:121503787-121504483 | bone marrow | dendritic cell lineage | NA |
| E_01347 | chr8:121503787-121504483 | bone marrow | dendritic cell lineage | NA |
| E_03073 | chr8:121503787-121504483 | bone marrow | plasmacytoid dendritic cell | NA |
| E_03105 | chr8:121503787-121504483 | bone marrow | dendritic cell progenitor | NA |
| E_03106 | chr8:121503787-121504483 | bone marrow | conventional dendritic cell precursor | NA |
| E_03107 | chr8:121503787-121504483 | bone marrow | conventional dendritic cell precursor | NA |
Expression of Target Genes for the Enhancer