About Enhancer
| Enhancer ID: | E_01170 |
| Species: | Homo sapiens |
| Position : | chr17:38065200-38065700   |
| Year: | 2016 |
| Title: | 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | asthma |
| PMID: | 27848966 |
| MONDO: | MONDO:0004607 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | HUT-78 |
| CVCL ID: | CVCL_0337 |
| Cell Type: | T lymphoma cell |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, 4C-seq, RNA-seq, DNase-seq |
| Low Throughput Method: | ChIP-qPCR, Allele-specific ChIP, RT-qPCR, siRNA knockdown, Flow cytometry, Cytokine ELISA, Sanger sequencing |
About TF
| TF name : | CTCF; IRF1; PAX4; TCF3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00821 | chr17:38065000-38068000 | Peripheral blood | CD4-positive T cell | -- |
| E_01166 | chr17:38065200-38065700 | Blood | CD4-positive T cell | asthma |
| E_01167 | chr17:38065200-38065700 | Lymphoid tissue | CD8-positive T cell | asthma |
| E_01168 | chr17:38065200-38065700 | Blood | B cell | asthma |
| E_01169 | chr17:38065200-38065700 | Blood | NK cell | asthma |
| E_00423 | chr17:38065500-38067500 | Blood | CD4-positive T cell | -- |
| E_00424 | chr17:38065500-38067500 | Blood | T lymphoma cell | cutaneous T-cell lymphoma |
Expression of Target Genes for the Enhancer