About Enhancer
| Enhancer ID: | E_01188 |
| Species: | Homo sapiens |
| Position : | chr4:15450000-15579703   |
| Year: | 2020 |
| Title: | H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute monocytic leukemia |
| PMID: | 32242051 |
| MONDO: | MONDO:0005025 |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | THP-1 |
| CVCL ID: | CVCL_0006 |
| Cell Type: | acute monocytic leukemia cell |
| Cell Ontology ID: | CL:0000576 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, Capture-C, RNA-seq |
| Low Throughput Method: | ChIP-qPCR, RT-qPCR, Western blot |
About Target Gene
| Target gene : | PROM1 |
About TF
| TF name : | MLL-AF4; EZH2; WILD-TYPE MLL |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00718 | chr4:15450000-15579703 | Bone Marrow | B lymphoblast | acute lymphoblastic leukemia |
| E_00719 | chr4:15450000-15579703 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00720 | chr4:15450000-15579703 | Bone Marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01184 | chr4:15450000-15579703 | Bone marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01185 | chr4:15450000-15579703 | Bone marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01186 | chr4:15450000-15579703 | Bone marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01187 | chr4:15450000-15579703 | Bone marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01189 | chr4:15450000-15579703 | Bone marrow | B lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01190 | chr4:15450000-15579703 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_01191 | chr4:15450000-15579703 | Bone marrow | hematopoietic stem cell | -- |
Expression of Target Genes for the Enhancer