About Enhancer
| Enhancer ID: | E_01196 |
| Species: | Homo sapiens |
| Position : | chr2:29880537-29880842   |
| Year: | 2017 |
| Title: | PAX3-FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | alveolar rhabdomyosarcoma |
| PMID: | 28446439 |
| MONDO: | MONDO:0005080 |
| Tissue: | Skeletal muscle |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | SCMC |
| CVCL ID: | CVCL_UC63 |
| Cell Type: | rhabdomyosarcoma cell |
| Cell Ontology ID: | CL:0000050 |
| Experiment Type: | Enhancer activity assay, Super-enhancer profiling |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | ALK |
About TF
| TF name : | PAX3-FOXO1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00909 | chr2:29411893-30163716 | Brain | medulloblastoma cell | medulloblastoma |
| E_01195 | chr2:29880537-29880842 | Skeletal muscle | rhabdomyosarcoma cell | alveolar rhabdomyosarcoma |
| E_01197 | chr2:29880537-29880842 | Skeletal muscle | rhabdomyosarcoma cell | alveolar rhabdomyosarcoma |
Expression of Target Genes for the Enhancer