About Enhancer
| Enhancer ID: | E_01198 |
| Species: | Homo sapiens |
| Position : | chr17:37900000-37900500   |
| Year: | 2017 |
| Title: | A novel HER2 gene body enhancer contributes to HER2 expression |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast adenocarcinoma |
| PMID: | 29035388 |
| MONDO: | MONDO:0004982 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | SKBR3 breast cancer cell line |
| CVCL ID: | CVCL_0033 |
| Cell Type: | breast adenocarcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Enhancer functional assay, TF binding assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | ERBB2 |
About TF
| TF name : | TFAP2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TFAP2C | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer