About Enhancer
| Enhancer ID: | E_01206 |
| Species: | Homo sapiens |
| Position : | chr13:40800660-40848941   |
| Year: | 2020 |
| Title: | Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | alveolar rhabdomyosarcoma |
| PMID: | 32416589 |
| MONDO: | MONDO:0005080 |
| Tissue: | Skeletal muscle |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | RH30 rhabdomyosarcoma cell lines |
| CVCL ID: | CVCL_1648 |
| Cell Type: | rhabdomyosarcoma cell |
| Cell Ontology ID: | CL:0000050 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | ChIP-seq, 3C-seq, 4C-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-qPCR, RT-qPCR, Sanger Sequencing |
About Target Gene
| Target gene : | FOXO1 |
About TF
| TF name : | MYOG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYOG | CDO in myogenesis | reactome | 29 |
| MYOG | ID | netpath | 38 |
| MYOG | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| MYOG | Hs_Hypertrophy_Model_WP516_88898 | wikipathways | 17 |
| MYOG | Hs_Wnt_Signaling_Pathway_WP428_90292 | wikipathways | 7 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01205 | chr13:40800660-40848941 | Skeletal muscle | rhabdomyosarcoma cell | alveolar rhabdomyosarcoma |
Expression of Target Genes for the Enhancer