About Enhancer
| Enhancer ID: | E_01212 |
| Species: | Homo sapiens |
| Position : | chr21:42660000-42661000   |
| Year: | 2020 |
| Title: | Ligand dependent gene regulation by transient ER?|?? clustered enhancers |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast adenocarcinoma |
| PMID: | 31905229 |
| MONDO: | MONDO:0004982 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 breast cancer cell line |
| CVCL ID: | CVCL_0031 |
| Cell Type: | breast adenocarcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, 5C, ChIA-PET |
| Low Throughput Method: | CRISPR Knockout, RT-qPCR, ImmunoFISH |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | ESR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ESR1 | AndrogenReceptor | netpath | 167 |
| ESR1 | AP-1 transcription factor network | pid | 71 |
| ESR1 | ATF-2 transcription factor network | pid | 59 |
| ESR1 | Cellular roles of Anthrax toxin | pid | 25 |
| ESR1 | FOXA1 transcription factor network | pid | 45 |
| ESR1 | FOXM1 transcription factor network | pid | 43 |
| ESR1 | Leptin | netpath | 98 |
| ESR1 | LKB1 signaling events | pid | 43 |
| ESR1 | Nuclear Receptor transcription pathway | reactome | 51 |
| ESR1 | Nuclear signaling by ERBB4 | reactome | 25 |
| ESR1 | Plasma membrane estrogen receptor signaling | pid | 42 |
| ESR1 | Prolactin | netpath | 105 |
| ESR1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| ESR1 | Regulation of Telomerase | pid | 70 |
| ESR1 | Signaling events mediated by HDAC Class II | pid | 58 |
| ESR1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| ESR1 | Tamoxifen Action Pathway | smpdb | 10 |
| ESR1 | Tamoxifen Metabolism Pathway | smpdb | 10 |
| ESR1 | TGF_beta_Receptor | netpath | 220 |
| ESR1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| ESR1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| ESR1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| ESR1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| ESR1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| ESR1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer