About Enhancer
| Enhancer ID: | E_01240 |
| Species: | Homo sapiens |
| Position : | chr11:5241525-5251525   |
| Year: | 2016 |
| Title: | Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 27863249 |
| MONDO: | |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary erythroblasts |
| CVCL ID: | |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, RT-qPCR |
About Target Gene
| Target gene : | HBB |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01117 | chr11:5246500-5247000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00399 | chr11:5246600-5247600 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00400 | chr11:5246600-5247600 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00288 | chr11:5248250-5249100 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer