About Enhancer
| Enhancer ID: | E_01243 |
| Species: | Mus musculus |
| Position : | chr1:63193000-63196000   |
| Year: | 2019 |
| Title: | Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from na?ve pluripotency. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30990414 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic stem cells (mESCs) |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | 4C-seq; ATAC-seq; ChIP-seq; RNA-seq; WGBS; DNA methylation profiling |
| Low Throughput Method: | CRISPR Knockout; ChIP-RT-qPCR; RT-RT-qPCR; Bisulfite Pyrosequencing |
About Target Gene
| Target gene : | Zdbf2 |
About TF
| TF name : | Pou5f1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5f1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5f1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5f1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5f1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer