About Enhancer
| Enhancer ID: | E_01254 |
| Species: | Homo sapiens |
| Position : | chr8:130180000-130181000   |
| Year: | 2018 |
| Title: | ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 29326336 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | CCRF-CEM |
| CVCL ID: | CVCL_0207 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, functional perturbation assay |
| High Throughput Method: | ChIP-seq, ChIA-PET |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | ARID5B |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ARID5B | HDMs demethylate histones | reactome | 49 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01253 | chr8:130180000-130181000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00452 | chr8:130180065-130180972 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00325 | chr8:130180217-130180629 | Peripheral Blood | T cell | adult T-cell leukemia/lymphoma |
Expression of Target Genes for the Enhancer