About Enhancer
| Enhancer ID: | E_01257 |
| Species: | Mus musculus |
| Position : | chr12:3946672-3948652   |
| Year: | 2015 |
| Title: | Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program. |
| Genome Build: | mm8 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25605944 |
| Tissue: | pituitary gland |
| Tissue Ontology ID: | UBERON:0000007 |
| Cell Source: | AtT-20 |
| CVCL ID: | CVCL_2300 |
| Cell Type: | corticotroph |
| Cell Ontology ID: | CL:0002309 |
| Experiment Type: | Enhancer activity assay; Enhancer-promoter looping assay; Functional perturbation assay; Transcriptional regulation assay |
| High Throughput Method: | ASCL1 ChIP-seq; LDB1 ChIP-seq; TBX19 ChIP-seq; EP300 ChIP-seq; H3K27ac ChIP-seq; H3K4me1 ChIP-seq; GRO-seq |
| Low Throughput Method: | ASCL1 knockdown; LDB1 knockdown; transient reporter assay; 3C-qPCR; PE3C-DSL; ChIP-qPCR; co-immunoprecipitation; mass spectrometry; RT-qPCR; Western blot |
About Target Gene
| Target gene : | Pomc |
About TF
| TF name : | Ascl1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ascl1 | Notch-mediated HES/HEY network | pid | 48 |
| Ascl1 | Notch | netpath | 76 |
| Ascl1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Ascl1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (mm8)
4 found
Expression of Target Genes for the Enhancer