About Enhancer
| Enhancer ID: | E_01269 |
| Species: | Homo sapiens |
| Position : | chr4:145678450-145679450   |
| Year: | 2020 |
| Title: | Fine-mapping of the 4q3122 locus identifies potential causal variants and enhancers for premenopausal breast cancer risk |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 31087647 |
| MONDO: | |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | HMEC |
| CVCL ID: | CVCL_U869 |
| Cell Type: | mammary epithelial cell |
| Cell Ontology ID: | CL:0002321 |
| Experiment Type: | TF binding assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | EDNRA |
About TF
| TF name : | FOS |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOS | Activation of the AP-1 family of transcription factors | reactome | 10 |
| FOS | Alpha6Beta4Integrin | netpath | 74 |
| FOS | Angiogenesis | panther | 141 |
| FOS | AP-1 transcription factor network | pid | 71 |
| FOS | Apoptosis signaling pathway | panther | 104 |
| FOS | ATF-2 transcription factor network | pid | 59 |
| FOS | B cell activation | panther | 52 |
| FOS | BCR | netpath | 161 |
| FOS | BCR signaling pathway | pid | 70 |
| FOS | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| FOS | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| FOS | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| FOS | EGFR1 | netpath | 475 |
| FOS | Endothelins | pid | 64 |
| FOS | ErbB1 downstream signaling | pid | 105 |
| FOS | ErbB2/ErbB3 signaling events | pid | 41 |
| FOS | Fc-epsilon receptor I signaling in mast cells | pid | 64 |
| FOS | FCERI mediated MAPK activation | reactome | 40 |
| FOS | FGF signaling pathway | pid | 55 |
| FOS | FOXA1 transcription factor network | pid | 45 |
| FOS | FOXM1 transcription factor network | pid | 43 |
| FOS | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOS | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOS | Glucocorticoid receptor regulatory network | pid | 85 |
| FOS | GMCSF-mediated signaling events | pid | 38 |
| FOS | HIF-1-alpha transcription factor network | pid | 67 |
| FOS | Huntington disease | panther | 113 |
| FOS | IL12-mediated signaling events | pid | 62 |
| FOS | IL12 signaling mediated by STAT4 | pid | 33 |
| FOS | IL2-mediated signaling events | pid | 54 |
| FOS | IL6-mediated signaling events | pid | 48 |
| FOS | IL6 | netpath | 85 |
| FOS | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | panther | 29 |
| FOS | Interleukin signaling pathway | panther | 86 |
| FOS | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOS | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOS | LPA receptor mediated events | pid | 65 |
| FOS | Nongenotropic Androgen signaling | pid | 31 |
| FOS | Osteopontin-mediated events | pid | 32 |
| FOS | Oxidative Stress Induced Senescence | reactome | 120 |
| FOS | PDGF signaling pathway | panther | 113 |
| FOS | PDGFR-alpha signaling pathway | pid | 22 |
| FOS | PDGFR-beta signaling pathway | pid | 125 |
| FOS | Presenilin action in Notch and Wnt signaling | pid | 46 |
| FOS | Prolactin | netpath | 105 |
| FOS | Ras signaling in the CD4+ TCR pathway | pid | 14 |
| FOS | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| FOS | Regulation of Telomerase | pid | 70 |
| FOS | RhoA signaling pathway | pid | 46 |
| FOS | S1P2 pathway | pid | 26 |
| FOS | Senescence-Associated Secretory Phenotype (SASP) | reactome | 108 |
| FOS | T cell activation | panther | 60 |
| FOS | TCR | netpath | 261 |
| FOS | TGF_beta_Receptor | netpath | 220 |
| FOS | TP53 Regulates Transcription of DNA Repair Genes | reactome | 61 |
| FOS | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| FOS | MAPK signaling pathway | kegg | 264 |
| FOS | Toll-like receptor signaling pathway | kegg | 100 |
| FOS | T cell receptor signaling pathway | kegg | 105 |
| FOS | B cell receptor signaling pathway | kegg | 70 |
| FOS | Leishmaniasis | kegg | 71 |
| FOS | Chagas disease | kegg | 103 |
| FOS | Pathways in cancer | kegg | 321 |
| FOS | Colorectal cancer | kegg | 63 |
| FOS | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
| FOS | Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293 | wikipathways | 71 |
| FOS | Hs_Serotonin_and_anxiety-related_events_WP3944_90836 | wikipathways | 9 |
| FOS | Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 | wikipathways | 34 |
| FOS | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| FOS | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
| FOS | Hs_IL-5_Signaling_Pathway_WP127_78498 | wikipathways | 35 |
| FOS | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
| FOS | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
| FOS | Hs_IL-3_Signaling_Pathway_WP286_78583 | wikipathways | 35 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer