About Enhancer
| Enhancer ID: | E_01277 |
| Species: | Homo sapiens |
| Position : | chr14:98602411-98675204   |
| Year: | 2023 |
| Title: | Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 37060567 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary Human T-ALL Cells |
| CVCL ID: | |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C, 4C-seq |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR |
About Target Gene
| Target gene : | TLX3 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00252 | chr14:98602411-98675204 | Bone Marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00253 | chr14:98602411-98675204 | Bone Marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00254 | chr14:98602411-98675204 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_01276 | chr14:98602411-98675204 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer