About Enhancer
| Enhancer ID: | E_01293 |
| Species: | Homo sapiens |
| Position : | chr8:128753000-128754000   |
| Year: | 2014 |
| Title: | FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | endometrial adenocarcinoma |
| PMID: | 24512546 |
| MONDO: | MONDO:0005047 |
| Tissue: | Endometrium |
| Tissue Ontology ID: | UBERON:0001295 |
| Cell Source: | MFE-296 |
| CVCL ID: | CVCL_1406 |
| Cell Type: | endometrial adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00419 | chr8:128740000-128790000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00646 | chr8:128747000-128753000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00945 | chr8:128747680-128753680 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_00595 | chr8:128748351-128800823 | Pulmonary artery | pulmonary artery endothelial cell | -- |
| E_00596 | chr8:128748351-128800823 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00167 | chr8:128750000-129000000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00606 | chr8:128751884-128753219 | Colon | colon epithelial cell | -- |
| E_01104 | chr8:128754000-128755000 | Breast | breast carcinoma cell | breast carcinoma |
| E_01105 | chr8:128754000-128755000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer