About Enhancer
| Enhancer ID: | E_01299 |
| Species: | Homo sapiens |
| Position : | chr10:52430000-52490000   |
| Year: | 2024 |
| Title: | DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 39107271 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | AsPC-1 |
| CVCL ID: | CVCL_0152 |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C, ATAC-seq, RNA-seq, DNase-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, DNA pull-down assay |
About Target Gene
| Target gene : | DKK1 |
About TF
| TF name : | JUND; FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01297 | chr10:52430000-52490000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01298 | chr10:52430000-52490000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01379 | chr10:52442551-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01380 | chr10:52442551-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01381 | chr10:52442551-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01533 | chr10:52443227-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01534 | chr10:52443227-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01535 | chr10:52443227-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01612 | chr10:52443566-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01613 | chr10:52443566-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01614 | chr10:52443566-52444237 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01415 | chr10:52472214-52473981 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01416 | chr10:52472214-52473981 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01417 | chr10:52472214-52473981 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01382 | chr10:52485607-52487433 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01383 | chr10:52485607-52487433 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01418 | chr10:52488538-52489405 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01419 | chr10:52488538-52489405 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01420 | chr10:52488538-52489405 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer