About Enhancer
| Enhancer ID: | E_01303 |
| Species: | Homo sapiens |
| Position : | chr17:41792666-41793322   |
| Year: | 2023 |
| Title: | eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal adenocarcinoma |
| PMID: | 36803948 |
| MONDO: | MONDO:0004973 |
| Tissue: | Esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | OE19 |
| CVCL ID: | CVCL_1302 |
| Cell Type: | esophageal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, RNA-seq, ChIP-seq, Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR knockout/CRISPRi, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | GRB7 |
About TF
| TF name : | KLF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01301 | chr17:41792666-41793322 | Esophagus | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
| E_01302 | chr17:41792666-41793322 | Esophagus | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
| E_01304 | chr17:41792666-41793322 | Esophagus | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
Expression of Target Genes for the Enhancer