About Enhancer
| Enhancer ID: | E_01309 |
| Species: | Homo sapiens |
| Position : | chr20:63680288-63681605   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 40830415 |
| MONDO: | MONDO:0005142 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | LN229 cells |
| CVCL ID: | CVCL_0393 |
| Cell Type: | glioblastoma cell |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, CRISPR knockout, CRISPRi, RT-RT-qPCR |
About Target Gene
| Target gene : | SOX18 |
About TF
| TF name : | MEIS1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEIS1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01308 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_01310 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_00056 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00057 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00058 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00084 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00085 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00086 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00087 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00119 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00120 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00121 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00122 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
Expression of Target Genes for the Enhancer