About Enhancer
| Enhancer ID: | E_01332 |
| Species: | Homo sapiens |
| Position : | chr3:169000000-169001000   |
| Year: | 2023 |
| Title: | Epigenetic landscape reveals MECOM as an endothelial lineage regulator |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 37185814 |
| MONDO: | |
| Tissue: | Umbilical vein |
| Tissue Ontology ID: | UBERON:0002066 |
| Cell Source: | HUVEC |
| CVCL ID: | CVCL_2959 |
| Cell Type: | umbilical vein endothelial cell |
| Cell Ontology ID: | CL:0002615 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | KDR |
About TF
| TF name : | MECOM |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MECOM | PKMTs methylate histone lysines | reactome | 64 |
| MECOM | MAPK signaling pathway | kegg | 264 |
| MECOM | Pathways in cancer | kegg | 321 |
| MECOM | Chronic myeloid leukemia | kegg | 69 |
| MECOM | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer