About Enhancer
| Enhancer ID: | E_01335 |
| Species: | Homo sapiens |
| Position : | chr12:121799763-121803094   |
| Year: | 2023 |
| Title: | Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 37756562 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HepG2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | LINC01089 |
About TF
| TF name : | E2F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| E2F1 | Activation of PUMA and translocation to mitochondria | reactome | 8 |
| E2F1 | Association of licensing factors with the pre-replicative complex | reactome | 15 |
| E2F1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| E2F1 | CDC6 association with the ORC:origin complex | reactome | 11 |
| E2F1 | Cyclin D associated events in G1 | reactome | 38 |
| E2F1 | Direct p53 effectors | pid | 141 |
| E2F1 | E2F mediated regulation of DNA replication | reactome | 17 |
| E2F1 | E2F transcription factor network | pid | 77 |
| E2F1 | G0 and Early G1 | reactome | 25 |
| E2F1 | G1/S-Specific Transcription | reactome | 17 |
| E2F1 | G2 Phase | reactome | 5 |
| E2F1 | IL2 signaling events mediated by PI3K | pid | 38 |
| E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | reactome | 12 |
| E2F1 | Notch-mediated HES/HEY network | pid | 48 |
| E2F1 | Oncogene Induced Senescence | reactome | 30 |
| E2F1 | Oxidative Stress Induced Senescence | reactome | 120 |
| E2F1 | p75(NTR)-mediated signaling | pid | 74 |
| E2F1 | Pre-NOTCH Transcription and Translation | reactome | 29 |
| E2F1 | Regulation of retinoblastoma protein | pid | 67 |
| E2F1 | Regulation of Telomerase | pid | 70 |
| E2F1 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | reactome | 13 |
| E2F1 | Cell cycle | kegg | 124 |
| E2F1 | Pathways in cancer | kegg | 321 |
| E2F1 | Pancreatic cancer | kegg | 70 |
| E2F1 | Glioma | kegg | 65 |
| E2F1 | Prostate cancer | kegg | 85 |
| E2F1 | Melanoma | kegg | 69 |
| E2F1 | Bladder cancer | kegg | 38 |
| E2F1 | Chronic myeloid leukemia | kegg | 69 |
| E2F1 | Small cell lung cancer | kegg | 83 |
| E2F1 | Non-small cell lung cancer | kegg | 54 |
| E2F1 | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| E2F1 | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| E2F1 | Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697 | wikipathways | 30 |
| E2F1 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| E2F1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| E2F1 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
| E2F1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
| E2F1 | Hs_Bladder_Cancer_WP2828_89143 | wikipathways | 17 |
| E2F1 | Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 | wikipathways | 16 |
| E2F1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| E2F1 | Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 | wikipathways | 14 |
| E2F1 | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01334 | chr12:121799763-121803094 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01336 | chr12:121799763-121803094 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01337 | chr12:121799763-121803094 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer