About Enhancer
| Enhancer ID: | E_01344 |
| Species: | Mus musculus |
| Position : | chr8:121495079-121495626   |
| Year: | 2023 |
| Title: | Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36990511 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | maturing cDC1 cells |
| Cell Type: | dendritic cell lineage |
| Experiment Type: | TF binding assay; Chromatin interaction assay; Endogenous enhancer perturbation assay |
| High Throughput Method: | RNA-seq; ATAC-seq; ChIP-seq; 4C-seq |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; compound enhancer genetics; BATF3 occupancy analysis; flow cytometry; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Batf3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Batf3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Batf3 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer