About Enhancer
| Enhancer ID: | E_01345 |
| Species: | Homo sapiens |
| Position : | chr3:186239308-186239606   |
| Year: | 2026 |
| Title: | Species-specific chromatin architecture and neurogenesis mediated by a human enhancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 41357990 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Cortical organoids |
| CVCL ID: | |
| Cell Type: | cortical organoid |
| Cell Ontology ID: | CL:0002672 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | Hi-C, RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, CRISPRi, ChIP-RT-qPCR, Transgenic reporter assay, FISH |
About Target Gene
| Target gene : | TRA2B |
About TF
| TF name : | ETV5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ETV5 | AndrogenReceptor | netpath | 167 |
| ETV5 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ETV5 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ETV5 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ETV5 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ETV5 | FOXM1 transcription factor network | pid | 43 |
| ETV5 | IL12 signaling mediated by STAT4 | pid | 33 |
| ETV5 | RANKL | netpath | 84 |
| ETV5 | RhoA signaling pathway | pid | 46 |
| ETV5 | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer