About Enhancer
| Enhancer ID: | E_01345 |
| Species: | Mus musculus |
| Position : | chr8:121495079-121495626   |
| Year: | 2023 |
| Title: | Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36990511 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | maturing cDC1 cells |
| Cell Type: | dendritic cell lineage |
| Experiment Type: | Enhancer activity/occupancy assay; Chromatin interaction assay; Endogenous enhancer perturbation assay |
| High Throughput Method: | RNA-seq; ATAC-seq; ChIP-seq; 4C-seq |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; compound-heterozygous mouse genetics; flow cytometry; RT-qPCR; chromatin-accessibility/occupancy validation; CRISPR-Cas9 |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Irf8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf8 | GMCSF-mediated signaling events | pid | 38 |
| Irf8 | Interferon alpha/beta signaling | reactome | 67 |
| Irf8 | Interferon gamma signaling | reactome | 88 |
| Irf8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Irf8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer