About Enhancer
| Enhancer ID: | E_01346 |
| Species: | Homo sapiens |
| Position : | chr10:35949493-35950111   |
| Year: | 2025 |
| Title: | A human-specific enhancer fine tunes radial glia potency and corticogenesis |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40369080 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Radial glial cells |
| CVCL ID: | |
| Cell Type: | radial glial cell |
| Cell Ontology ID: | CL:0000681 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, Hi-C, RNA-seq |
| Low Throughput Method: | CRISPR knockout, Luciferase reporter assay |
About Target Gene
| Target gene : | FZD8 |
About TF
| TF name : | TCF7L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF7L2 | Alzheimer disease-presenilin pathway | panther | 98 |
| TCF7L2 | Angiogenesis | panther | 141 |
| TCF7L2 | AP-1 transcription factor network | pid | 71 |
| TCF7L2 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| TCF7L2 | Ca2+ pathway | reactome | 62 |
| TCF7L2 | Cadherin signaling pathway | panther | 147 |
| TCF7L2 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| TCF7L2 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF7L2 | ID | netpath | 38 |
| TCF7L2 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| TCF7L2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF7L2 | Repression of WNT target genes | reactome | 14 |
| TCF7L2 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| TCF7L2 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| TCF7L2 | Wnt | netpath | 118 |
| TCF7L2 | Wnt signaling pathway | panther | 250 |
| TCF7L2 | Wnt signaling pathway | kegg | 135 |
| TCF7L2 | Adherens junction | kegg | 70 |
| TCF7L2 | Melanogenesis | kegg | 100 |
| TCF7L2 | Pathways in cancer | kegg | 321 |
| TCF7L2 | Colorectal cancer | kegg | 63 |
| TCF7L2 | Endometrial cancer | kegg | 52 |
| TCF7L2 | Prostate cancer | kegg | 85 |
| TCF7L2 | Acute myeloid leukemia | kegg | 53 |
| TCF7L2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03472 | chr10:35949193-35950411 | cerebral cortex | radial glial cell | NA |
Expression of Target Genes for the Enhancer