About Enhancer
| Enhancer ID: | E_01347 |
| Species: | Mus musculus |
| Position : | chr8:121503787-121504483   |
| Year: | 2023 |
| Title: | Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36990511 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | pre-cDC1 / dendritic progenitors |
| Cell Type: | dendritic cell lineage |
| Experiment Type: | Enhancer activity/occupancy assay; Chromatin interaction assay; Endogenous enhancer perturbation assay |
| High Throughput Method: | RNA-seq; ATAC-seq; ChIP-seq; 4C-seq |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; mouse genetics; flow cytometry; RT-qPCR; E-box functional analysis; CRISPR-Cas9 |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Tcf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf4 | AndrogenReceptor | netpath | 167 |
| Tcf4 | CDO in myogenesis | reactome | 29 |
| Tcf4 | Coregulation of Androgen receptor activity | pid | 61 |
| Tcf4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf4 | ID | netpath | 38 |
| Tcf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf4 | TGF_beta_Receptor | netpath | 220 |
| Tcf4 | Wnt | netpath | 118 |
| Tcf4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (mm39)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01166 | chr8:121503787-121504483 | bone marrow | dendritic cell progenitor | NA |
| E_01346 | chr8:121503787-121504483 | bone marrow | dendritic cell lineage | NA |
| E_03073 | chr8:121503787-121504483 | bone marrow | plasmacytoid dendritic cell | NA |
| E_03105 | chr8:121503787-121504483 | bone marrow | dendritic cell progenitor | NA |
| E_03106 | chr8:121503787-121504483 | bone marrow | conventional dendritic cell precursor | NA |
| E_03107 | chr8:121503787-121504483 | bone marrow | conventional dendritic cell precursor | NA |
Expression of Target Genes for the Enhancer