About Enhancer
| Enhancer ID: | E_01356 |
| Species: | Homo sapiens |
| Position : | chr17:41268000-41269000   |
| Year: | 2025 |
| Title: | MAPK3 Modulates Enhancer-Promoter Interactions of SKAP2 in Acute Myeloid Leukemia |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 41139207 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | KG1a cells |
| CVCL ID: | CVCL_1824 |
| Cell Type: | acute myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | CRISPR knockout, 3C-RT-qPCR, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | SKAP2 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01705 | chr17:40880001-41560000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_01355 | chr17:41268000-41269000 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_01357 | chr17:41268000-41269000 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_01358 | chr17:41268000-41269000 | Bone marrow | acute promyelocytic leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer