About Enhancer
| Enhancer ID: | E_01357 |
| Species: | Mus musculus |
| Position : | chr1:136180500-136180903   |
| Year: | 2017 |
| Title: | MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28575289 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast/myotube |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq, 3C-seq |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; CRISPR Knockout; RT-RT-qPCR, 3C-PCR |
About Target Gene
| Target gene : | Myog |
About TF
| TF name : | Myod1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Myod1 | C-MYB transcription factor network | pid | 87 |
| Myod1 | CDO in myogenesis | reactome | 29 |
| Myod1 | ID | netpath | 38 |
| Myod1 | Notch-mediated HES/HEY network | pid | 48 |
| Myod1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Myod1 | Regulation of retinoblastoma protein | pid | 67 |
| Myod1 | Signaling events mediated by HDAC Class III | pid | 41 |
| Myod1 | Hs_ID_signaling_pathway_WP53_67360 | wikipathways | 8 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer