About Enhancer
| Enhancer ID: | E_01370 |
| Species: | Mus musculus |
| Position : | chr15:63087071-63087595   |
| Year: | 2014 |
| Title: | Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25369933 |
| MONDO: | MONDO:0004963 |
| Cell Source: | T6E murine T-ALL cells |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | Notch1 ChIP-seq; Rbpj ChIP-seq; Histone modification ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay; EMSA; 3C-qPCR; ChIP-qPCR; Site-directed mutagenesis; Gamma-secretase inhibition; qRT-PCR |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | Notch1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Notch1 | A third proteolytic cleavage releases NICD | reactome | 9 |
| Notch1 | Activated NOTCH1 Transmits Signal to the Nucleus | reactome | 30 |
| Notch1 | Alzheimer disease-presenilin pathway | panther | 98 |
| Notch1 | Angiogenesis | panther | 141 |
| Notch1 | C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 8 |
| Notch1 | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| Notch1 | Constitutive Signaling by NOTCH1 HD Domain Mutants | reactome | 15 |
| Notch1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| Notch1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| Notch1 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | reactome | 7 |
| Notch1 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | reactome | 5 |
| Notch1 | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| Notch1 | NICD traffics to nucleus | reactome | 13 |
| Notch1 | Notch-HLH transcription pathway | reactome | 13 |
| Notch1 | Notch-mediated HES/HEY network | pid | 48 |
| Notch1 | Notch | netpath | 76 |
| Notch1 | Notch degradation signaling ( Notch signaling pathway Diagram ) | inoh | 5 |
| Notch1 | Notch degradation signaling (Mammal) ( Notch signaling pathway Diagram ) | inoh | 5 |
| Notch1 | Notch secretory pathway ( Notch signaling pathway Diagram ) | inoh | 5 |
| Notch1 | Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram ) | inoh | 5 |
| Notch1 | Notch signaling pathway | panther | 27 |
| Notch1 | Notch signaling pathway | pid | 58 |
| Notch1 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Notch1 | Pre-NOTCH Processing in Golgi | reactome | 18 |
| Notch1 | Pre-NOTCH Processing in the Endoplasmic Reticulum | reactome | 6 |
| Notch1 | Pre-NOTCH Transcription and Translation | reactome | 29 |
| Notch1 | Presenilin action in Notch and Wnt signaling | pid | 46 |
| Notch1 | Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor | reactome | 14 |
| Notch1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| Notch1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Notch1 | Dorso-ventral axis formation | kegg | 25 |
| Notch1 | Notch signaling pathway | kegg | 44 |
| Notch1 | Hs_Gastric_Cancer_Network_1_WP2361_86831 | wikipathways | 26 |
| Notch1 | Hs_PI3K-AKT-mTOR_signaling_pathway_and_therapeutic_opportunities_WP3844_89952 | wikipathways | 5 |
| Notch1 | Hs_Primary_Focal_Segmental_Glomerulosclerosis_FSGS_WP2572_90019 | wikipathways | 7 |
| Notch1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Notch1 | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| Notch1 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Notch1 | Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 | wikipathways | 12 |
| Notch1 | Hs_Amplification_and_Expansion_of_Oncogenic_Pathways_as_Metastatic_Traits_WP3678_90110 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01371 | chr15:63087071-63087595 | NA | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer