About Enhancer
| Enhancer ID: | E_01374 |
| Species: | Homo sapiens |
| Position : | chr10:61960755-61962481   |
| Year: | 2021 |
| Title: | Molecular Mechanisms of ARID5B-Mediated Genetic Susceptibility to Acute Lymphoblastic Leukemia |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 35575404 |
| MONDO: | MONDO:0004945 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Nalm6 |
| CVCL ID: | CVCL_0092 |
| Cell Type: | B lymphoblast |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPR Knockout, CRISPRi, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | ARID5B |
About TF
| TF name : | MEF2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEF2C | CDO in myogenesis | reactome | 29 |
| MEF2C | Circadian Clock | reactome | 49 |
| MEF2C | ErbB1 downstream signaling | pid | 105 |
| MEF2C | ERK/MAPK targets | reactome | 17 |
| MEF2C | Notch | netpath | 76 |
| MEF2C | Oxidative stress response | panther | 23 |
| MEF2C | p38 MAPK pathway | panther | 31 |
| MEF2C | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| MEF2C | Regulation of retinoblastoma protein | pid | 67 |
| MEF2C | Signaling events mediated by HDAC Class II | pid | 58 |
| MEF2C | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| MEF2C | TGF_beta_Receptor | netpath | 220 |
| MEF2C | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| MEF2C | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| MEF2C | MAPK signaling pathway | kegg | 264 |
| MEF2C | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| MEF2C | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| MEF2C | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| MEF2C | Hs_Oxidation_by_Cytochrome_P450_WP43_84102 | wikipathways | 14 |
| MEF2C | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer