About Enhancer
| Enhancer ID: | E_01377 |
| Species: | Mus musculus |
| Position : | chr1:136170803-136192554   |
| Year: | 2017 |
| Title: | MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 28575289 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast/myotube |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq; RNA-seq, 3C-seq |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; CRISPR Knockout; RT-RT-qPCR; Western blot; Immunofluorescence Staining |
About Target Gene
| Target gene : | Myog |
About TF
| TF name : | Myod1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Myod1 | C-MYB transcription factor network | pid | 87 |
| Myod1 | CDO in myogenesis | reactome | 29 |
| Myod1 | ID | netpath | 38 |
| Myod1 | Notch-mediated HES/HEY network | pid | 48 |
| Myod1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Myod1 | Regulation of retinoblastoma protein | pid | 67 |
| Myod1 | Signaling events mediated by HDAC Class III | pid | 41 |
| Myod1 | Hs_ID_signaling_pathway_WP53_67360 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01354 | chr1:136170800-136171203 | skeletal muscle tissue | myoblast/myotube | NA |
| E_01406 | chr1:136170878-136192613 | NA | NA | NA |
| E_01407 | chr1:136170878-136192613 | NA | NA | NA |
| E_01355 | chr1:136171700-136172103 | skeletal muscle tissue | myoblast/myotube | NA |
| E_01356 | chr1:136177900-136178345 | skeletal muscle tissue | myoblast/myotube | NA |
| E_01405 | chr1:136179600-136180045 | skeletal muscle tissue | myoblast | NA |
| E_01391 | chr1:136179654-136180057 | skeletal muscle tissue | myoblast | NA |
| E_01357 | chr1:136180500-136180903 | skeletal muscle tissue | myoblast/myotube | NA |
| E_01358 | chr1:136184128-136184880 | skeletal muscle tissue | myoblast/myotube | NA |
| E_01392 | chr1:136185854-136186299 | skeletal muscle tissue | myoblast | NA |
| E_01409 | chr1:136188400-136188845 | skeletal muscle tissue | myoblast | NA |
| E_01393 | chr1:136188454-136188857 | skeletal muscle tissue | myoblast | NA |
Expression of Target Genes for the Enhancer