About Enhancer
| Enhancer ID: | E_01386 |
| Species: | Homo sapiens |
| Position : | chr6:396104-396604   |
| Year: | 2023 |
| Title: | Cell type directed design of synthetic enhancers |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | skin melanoma |
| PMID: | 38086419 |
| MONDO: | MONDO:0005105 |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | Human melanoma cell |
| CVCL ID: | |
| Cell Type: | melanoma cell |
| Cell Ontology ID: | CL:0002573 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPRi, CRISPR Knockout, RT-RT-qPCR, ChIP-RT-qPCR |
About Target Gene
| Target gene : | IRF4 |
About TF
| TF name : | SOX10 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX10 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer