About Enhancer
| Enhancer ID: | E_01390 |
| Species: | Mus musculus |
| Position : | chr7:3198900-3202780   |
| Year: | 2019 |
| Title: | Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 31422875 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | mouse embryonic stem cells |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Super-enhancer methylation dynamics; TF/chromatin-state coupling; endogenous allele-specific reporter; Enhancer activity assay; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq; WGBS; ATAC-seq |
| Low Throughput Method: | Endogenous allele-specific reporter; targeted enhancer perturbation; ChIP-qPCR; RT-qPCR; DNA FISH; immunofluorescence/confocal imaging; Allele-specific reporter assay; In vivo phenotyping |
About Target Gene
| Target gene : | NA |
About TF
| TF name : | Pou5f1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5f1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5f1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5f1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5f1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
25 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01936 | chr7:3183157-3229407 | NA | NA | NA |
| E_03800 | chr7:3193003-3218182 | NA | NA | NA |
| E_03801 | chr7:3193003-3218182 | NA | NA | NA |
| E_03802 | chr7:3193003-3218182 | NA | NA | NA |
| E_03803 | chr7:3193003-3218182 | NA | NA | NA |
| E_03804 | chr7:3193003-3218182 | NA | NA | NA |
| E_03805 | chr7:3193003-3218182 | NA | NA | NA |
| E_03806 | chr7:3193003-3218182 | NA | NA | NA |
| E_01352 | chr7:3198900-3202780 | embryo | epiblast-like cell | NA |
| E_01353 | chr7:3198900-3202780 | embryo | epiblast-like cell | NA |
| E_01389 | chr7:3198900-3202780 | embryo | embryonic stem cell | NA |
| E_03754 | chr7:3199567-3201439 | NA | NA | NA |
| E_03755 | chr7:3199567-3201439 | NA | NA | NA |
| E_03756 | chr7:3199567-3201439 | NA | NA | NA |
| E_03757 | chr7:3199567-3201439 | NA | NA | NA |
| E_03758 | chr7:3199567-3201439 | NA | NA | NA |
| E_03759 | chr7:3199567-3201439 | NA | NA | NA |
| E_03760 | chr7:3199567-3201439 | NA | NA | NA |
| E_03761 | chr7:3202646-3204360 | NA | NA | NA |
| E_03762 | chr7:3202646-3204360 | NA | NA | NA |
| E_03763 | chr7:3202646-3204360 | NA | NA | NA |
| E_03764 | chr7:3202646-3204360 | NA | NA | NA |
| E_03765 | chr7:3202646-3204360 | NA | NA | NA |
| E_03766 | chr7:3202646-3204360 | NA | NA | NA |
| E_03767 | chr7:3202646-3204360 | NA | NA | NA |
Expression of Target Genes for the Enhancer