About Enhancer
| Enhancer ID: | E_01391 |
| Species: | Homo sapiens |
| Position : | chr1:116544766-116545360   |
| Year: | 2022 |
| Title: | PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 36516256 |
| MONDO: | MONDO:0004945 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Nalm6 |
| CVCL ID: | CVCL_0092 |
| Cell Type: | B lymphoblast |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPR Knockout, CRISPRi, RT-RT-qPCR |
About Target Gene
| Target gene : | CD58 |
About TF
| TF name : | PAX5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX5 | C-MYB transcription factor network | pid | 87 |
| PAX5 | ID | netpath | 38 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01392 | chr1:116544766-116545360 | Blood | B lymphoblast | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer