About Enhancer
| Enhancer ID: | E_01395 |
| Species: | Homo sapiens |
| Position : | chr4:88008000-88010000   |
| Year: | 2025 |
| Title: | Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 41314977 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | H22 cells |
| CVCL ID: | CVCL_0321 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | RNA-seq, ChIP-seq, scRNA-seq |
| Low Throughput Method: | Luciferase reporter assay, CUT&Tag, ChIP-RT-qPCR, CRISPR knockout, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | SPP1 |
About TF
| TF name : | FLI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FLI1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| FLI1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| FLI1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| FLI1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| FLI1 | PDGF signaling pathway | panther | 113 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01393 | chr4:88008000-88010000 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01394 | chr4:88008000-88010000 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01396 | chr4:88008000-88010000 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer