About Enhancer
| Enhancer ID: | E_01399 |
| Species: | Mus musculus |
| Position : | chr15:63254341-63256341   |
| Year: | 2014 |
| Title: | Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25369933 |
| MONDO: | MONDO:0004963 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002370 |
| Cell Source: | primary murine T-ALL blasts and T-ALL cell models |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | TF occupancy; long-range enhancer-promoter interaction; drug-response functional assay |
| High Throughput Method: | NOTCH1/RBPJ/H3K27ac ChIP-seq; chromatin-state profiling |
| Low Throughput Method: | 3C/long-range contact assays; enhancer reporter and RBPJ-site mutation; gamma-secretase inhibition; BRD4 inhibition; RT-qPCR |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | Rbpj |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Rbpj | Alzheimer disease-presenilin pathway | panther | 98 |
| Rbpj | Angiogenesis | panther | 141 |
| Rbpj | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| Rbpj | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| Rbpj | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| Rbpj | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| Rbpj | NICD traffics to nucleus | reactome | 13 |
| Rbpj | Notch-HLH transcription pathway | reactome | 13 |
| Rbpj | Notch-mediated HES/HEY network | pid | 48 |
| Rbpj | Notch | netpath | 76 |
| Rbpj | Notch signaling pathway | panther | 27 |
| Rbpj | Notch signaling pathway | pid | 58 |
| Rbpj | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Rbpj | NOTCH2 intracellular domain regulates transcription | reactome | 12 |
| Rbpj | Pre-NOTCH Transcription and Translation | reactome | 29 |
| Rbpj | Presenilin action in Notch and Wnt signaling | pid | 46 |
| Rbpj | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| Rbpj | Notch signaling pathway | kegg | 44 |
| Rbpj | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer