About Enhancer
| Enhancer ID: | E_01401 |
| Species: | Homo sapiens |
| Position : | chr2:188184700-188185000   |
| Year: | 2024 |
| Title: | Coronary artery disease risk variant dampens CALCRL expression by reducing HSF binding to enhancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 38602103 |
| MONDO: | |
| Tissue: | Artery |
| Tissue Ontology ID: | UBERON:0001621 |
| Cell Source: | Endothelial cells |
| CVCL ID: | |
| Cell Type: | endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA, CRISPR Knockout |
About Target Gene
| Target gene : | CALCRL |
About TF
| TF name : | HSF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HSF1 | Attenuation phase | reactome | 28 |
| HSF1 | HSF1-dependent transactivation | reactome | 34 |
| HSF1 | HSF1 activation | reactome | 31 |
| HSF1 | p73 transcription factor network | pid | 80 |
| HSF1 | Regulation of HSF1-mediated heat shock response | reactome | 82 |
| HSF1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer