About Enhancer
| Enhancer ID: | E_01405 |
| Species: | Homo sapiens |
| Position : | chr6:32553535-32609681   |
| Year: | 2020 |
| Title: | A super enhancer controls expression and chromatin architecture within the MHC class II locus |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma |
| PMID: | 31753848 |
| MONDO: | MONDO:0002483 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Human Burkitt lymphoma cell |
| CVCL ID: | |
| Cell Type: | Burkitt lymphoma cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | CRISPR knockout, ChIP-RT-qPCR, RT-RT-qPCR, Flow cytometry |
About Target Gene
| Target gene : | HLA-DRB1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer