About Enhancer
| Enhancer ID: | E_01408 |
| Species: | Homo sapiens |
| Position : | chr1:154150500-154151000   |
| Year: | 2024 |
| Title: | A transcriptional enhancer regulates cardiac maturation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39196225 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | hPSC-CMs |
| CVCL ID: | |
| Cell Type: | cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | ACTN2 |
About TF
| TF name : | TEAD1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TEAD1 | PPARA activates gene expression | reactome | 113 |
| TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| TEAD1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer