About Enhancer
| Enhancer ID: | E_01411 |
| Species: | Mus musculus |
| Position : | chr2:45279107-45280206   |
| Year: | 2022 |
| Title: | Ablation of cDC2 development by triple mutations within the Zeb2 enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 35732734 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Hoxb8-immortalized dendritic-cell precursor system |
| Cell Type: | common dendritic progenitor |
| Cell Ontology ID: | CL:0001029 |
| Experiment Type: | TF competition at Zeb2 ?165-kb enhancer; endogenous triple-motif mutagenesis; lineage differentiation and in vivo functional validation |
| High Throughput Method: | CUT&RUN; ChIP-seq; RNA-seq |
| Low Throughput Method: | EMSA; enhancer reporter; CRISPR-Cas9 triple-motif editing in mice; flow cytometry; progenitor differentiation; ChIP; helminth-challenge phenotyping |
About Target Gene
| Target gene : | Zeb2 |
About TF
| TF name : | Nfil3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01348 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01349 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01350 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01378 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01379 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01380 | chr2:45279107-45280206 | bone marrow | Common dendritic progenitor | NA |
| E_01400 | chr2:45279107-45280206 | bone marrow | common dendritic progenitor | NA |
| E_01401 | chr2:45279107-45280206 | bone marrow | common dendritic progenitor | NA |
| E_01402 | chr2:45279107-45280206 | bone marrow | common dendritic progenitor | NA |
| E_01412 | chr2:45279107-45280206 | bone marrow | common dendritic progenitor | NA |
| E_01413 | chr2:45279107-45280206 | bone marrow | common dendritic progenitor | NA |
Expression of Target Genes for the Enhancer