About Enhancer
| Enhancer ID: | E_01420 |
| Species: | Homo sapiens |
| Position : | chr10:52488538-52489405   |
| Year: | 2024 |
| Title: | DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 39107271 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | AsPC-1 |
| CVCL ID: | CVCL_0152 |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Insulator activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPRi, ChIP-RT-qPCR |
About Target Gene
| Target gene : | DKK1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01297 | chr10:52430000-52490000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01298 | chr10:52430000-52490000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01299 | chr10:52430000-52490000 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01418 | chr10:52488538-52489405 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01419 | chr10:52488538-52489405 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer