About Enhancer
| Enhancer ID: | E_01432 |
| Species: | Homo sapiens |
| Position : | chr7:22755717-22757217   |
| Year: | 2023 |
| Title: | YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6 |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 37094986 |
| MONDO: | MONDO:0008315 |
| Tissue: | Tumor microenvironment |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | M2 macrophage |
| CVCL ID: | |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, ChIP-RT-qPCR |
About Target Gene
| Target gene : | IL6 |
About TF
| TF name : | YY1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer