About Enhancer
| Enhancer ID: | E_01439 |
| Species: | Homo sapiens |
| Position : | chr12:56075734-56076734   |
| Year: | 2025 |
| Title: | Enhancer RNA transcription pinpoints functional genetic variants linked to asthma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40164603 |
| MONDO: | |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | HASM cells |
| CVCL ID: | |
| Cell Type: | airway smooth muscle cell |
| Cell Ontology ID: | CL:0000192 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | GRO-seq, Micro-C, ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, CRISPR knockout, CRISPRi, RT-RT-qPCR |
About Target Gene
| Target gene : | GCNT1 |
About TF
| TF name : | NR3C1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR3C1 | AndrogenReceptor | netpath | 167 |
| NR3C1 | AP-1 transcription factor network | pid | 71 |
| NR3C1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| NR3C1 | Cellular roles of Anthrax toxin | pid | 25 |
| NR3C1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| NR3C1 | Glucocorticoid receptor regulatory network | pid | 85 |
| NR3C1 | IL2 | netpath | 81 |
| NR3C1 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR3C1 | PTK6 Expression | reactome | 5 |
| NR3C1 | Regulation of Androgen receptor activity | pid | 54 |
| NR3C1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| NR3C1 | Signaling events mediated by HDAC Class II | pid | 58 |
| NR3C1 | Neuroactive ligand-receptor interaction | kegg | 272 |
| NR3C1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| NR3C1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| NR3C1 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| NR3C1 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
| NR3C1 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01438 | chr12:56075734-56076734 | Lung | bronchial epithelial cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer